Cytochrome P450

P450

CYPs

Cytochrome P450

Related Products

Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in every class of organism, including Archaea, the p450 superfamily is believed to have originated from an ancestral gene that existed over 3 billion years ago. Repeated gene duplications have subsequently given rise to one of the largest of multigene families. These enzymes are notable both for the diversity of reactions that they catalyze and the range of chemically dissimilar substrates upon which they act. Cytochrome p450s support the oxidative, peroxidative and reductive metabolism of such endogenous and xenobiotic substrates as environmental pollutants, agrochemicals, plant allelochemicals, steroids, prostaglandins and fatty acids. In humans, Cytochrome p450s are best known for their central role in phase I drug metabolism where they are of critical importance to two of the most significant problems in clinical pharmacology: drug interactions and interindividual variability in drug metabolism.

Cytochrome P450 Isoform Specific Products:

Cytochrome P450 Isoform Comparison

Cytochrome P450 Related Products (820)
Antibodies (25)
Cytochrome P450 Isoform Comparison

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By Effects:	Controls (3) Inhibitors (540) Substrates (12) Agonist (1) Degraders (2) Antagonists (2) Activators (54) Modulators (17) Inducers (23)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-146458

Antibacterial agent 102	Inhibitor
Antibacterial agent 102 (compound 32) possesses potent in vitro and in vivo antibacterial activity, with MICs < 0.5 μg/mL in Staphylococcus aureus (S. aureus). Antibacterial agent 102 also moderately inhibits CYP3A4 with an IC₅₀ value of 6.148 μM. Antibacterial agent 102 can reduce Methicillin-resistant Staphylococcus aureus (MRSA) load in thigh infected mice.

HY-116214S1

Cyprodinil-¹³C₆	Inducer
Cyprodinil-¹³C₆ (CGA-219417-¹³C₆) is the ¹³C₆ labeled Cyprodinil (HY-116214). Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens.

HY-121789

Proadifen	Inhibitor
Proadifen is a compound that inhibits cytochrome P450 activity, which can change the excitability of catecholamine-secreting neurons in the brain and have different effects on neurons in different brain regions.

HY-116643

SU 10603	Inhibitor
SU 10603 is a specific inhibitor of P45017α (P450c17; CYP17A1).

HY-115754

S-(N-PhenethylthiocarbaMoyl)-L-cysteine	Inhibitor
S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells. S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor.

HY-E70458

Human CYP3A4,High-Reductase
Human CYP3A4, High-Reductase, a recombinant CYP3A4, is a multifunctional enzyme with a wide range of substrates.

HY-162784

CYP51-IN-19	Inhibitor
CYP51-IN-19 (compound C07) is a potent CYP51 inhibitor. CYP51-IN-19 stimulates reactive oxygen species (ROS) and exhibits potent fungicidal activity.

HY-13832S3

cis-Atovaquone-d₄	Inhibitor
cis-Atovaquone-d₄ is deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].

HY-E70500

Human CYP4F3,Low-Reductase+b5
Human CYP4F3, Low-Reductase+b5, a recombinant CYP4F3, is a member of the CYP enzyme family. CYP4F3 is an enzyme mainly expressed in polymorphonuclear leukocytes.

HY-106019A

Liarozole hydrochloride	Inhibitor
Liarozole hydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole hydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of retinoic acid (IC₅₀=7 μM), resulting in increased tissue levels of retinoic acid. Liarozole hydrochloride shows antitumoral properties.

HY-151253

CYP2C1/CYP2C19-IN-2	Inhibitor
CYP2C1/CYP2C19-IN-2 (compound 21d) is a potent CYP2C9/CYP2C19 inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C1/CYP2C19-IN-2 can be used in study of anti-ZIKV.

HY-N3841R

ε-Viniferin (Standard)	Inhibitor
ε-Viniferin (Standard) is the analytical standard of ε-Viniferin. This product is intended for research and analytical applications. ε-Viniferin (epsilon-Viniferin), the dimer of Resveratrol and can be isolated from Vitis vinifera, displays a potent inhibitory for all the CYP activities, with Ki values from 0.5-20 μM. ε-Viniferin possesses potent antioxidant, anti-inflammatory, anti-diabetic, and anti-neurodegenerative capacity.

HY-N0382S

Galangin-¹³C₃	Inhibitor
Galangin-¹³C₃ is the ¹³C-labeled Galangin. Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity.

HY-14874S

Topiroxostat-d₄	Inhibitor
Topiroxostat-d₄ is deuterium labeled Topiroxostat. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment[1][2].

HY-E70485

Human CYP2C9,High-Reductase+b5
Human CYP2C9, High-Reductase+b5, a recombinant CYP2C9, is one of the most important cytochrome P450 (CYP) enzymes. Human CYP2C9, Low-Reductase is responsible for drug metabolism reactions that occur in human populations.

HY-135023

5-trans-PGE2	Activator
5-trans-PGE2 (5-trans Prostaglandin E2) is the active isomer of PGE2 and a potent activator of aromatase. Supplements the process of paracrine signaling between epithelial cells (expressing high levels of PGE2) and surrounding stromal cells (expressing high levels of aromatase). This process is involved in the growth and development of breast cancer.

HY-150581

CYP3A4-IN-3	Inhibitor
CYP3A4-IN-3 is a high-affinity specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC₅₀ value of 0.075 μM. CYP3A4-IN-3 is a ritonavir analogue, but with a simpler structure and twice the inhibitory effect of ritonavir. CYP3A4-IN-3 is used as an antiviral agent and immunosuppressant.

HY-N0125R

Diosmetin (Standard)	Inhibitor
Diosmetin (Standard) is the analytical standard of Diosmetin. This product is intended for research and analytical applications. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-172393

TCF4/β-catenin-IN-1	Inhibitor
TCF4/β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4/β-catenin, and induces apoptosis. TCF4/β-catenin-IN-1 up-regulates p53, caspase-3, caspase-8, caspase-9 levels and Bax protein expression as well as down-regulates Bcl-2 protein expression. TCF4/β-catenin-IN-1 can inhibit CYP3A4, CYP1A2, CYP2C19, and shows promising cytotoxic activity in cancer cells.

HY-118407

LY56110	Inhibitor
LY56110 is an orally active aromatase inhibitor. LY56110 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC₅₀ of 2.5 and 11 μΜ, respectively. LY56110 can be used for neurological disorder study.

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